Publications

Improving the future of early cancer detection through clinical studies.

Preliminary results for a novel single extracellular vesicle assay for early-stage ovarian cancer: The power of co-localized detection of surface biomarkers

OVARIAN CANCER

2022 American Association for Cancer Research Annual Meeting

These preliminary data suggest that co-localization of surface biomarkers in single EVs may provide an effective means to identify women with early-stage high-grade serous ovarian cancer (HGSOC), including those with normal CA125, while avoiding false positives in women with benign masses and high CA125. Despite the inherent challenges associated with commercial samples, our finding that several combinations detected early-stage HGSOC is promising. Statistically powered studies with curated repository specimens are underway to refine combinations and independently validate our assay for early-stage ovarian cancer detection.

Preliminary results for a novel single extracellular vesicle assay for early lung cancer: The power of co-localized detection of surface biomarkers

LUNG CANCER

2022 American Association for Cancer Research Annual Meeting

These preliminary data highlight the potential of detecting biomarkers co-localized on the surface of single EVs as an effective tool for early-stage lung cancer detection, and the benefit of using 3 biomarkers simultaneously. Despite inherent challenges associated with commercial samples, our finding that detection of co-localized EV surface biomarkers distinguished lung adenocarcinoma (LUAD) is promising. Additional studies with lung cancer cohorts beyond LUAD are underway to refine combinations and independently validate our assay for early-stage lung cancer detection.